Chiral ammonium betaine-catalyzed asymmetric Mannich-type reaction of oxindoles
نویسندگان
چکیده
A highly diastereo- and enantioselective Mannich-type reaction of 3-aryloxindoles with N-Boc aldimines was achieved under the catalysis of axially chiral ammonium betaines. This catalytic method provides a new tool for the construction of consecutive quaternary and tertiary stereogenic carbon centers on biologically intriguing molecular frameworks with high fidelity.
منابع مشابه
Flexible synthesis, structural determination, and synthetic application of a new C1-symmetric chiral ammonium betaine.
A C(1)-symmetric chiral ammonium betaine has been developed, and its intramolecular ion-pairing structure in solid state and its catalytic performance to achieve the highly stereoselective Mannich-type reaction of 2-alkoxythiazol-5(4H)-ones are revealed.
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